To get things rolling here's Christopher Lennertz' dead serious score for the comedy spoof "Meet The Spartans" (2008). It's a large orchestral effort that mainly skewers Tyler Bates' "300", with nods notably to Elfman's "Spider-Man" and "Edward Scissorhands" ("Land of Sparta", who would have known?) to name just a few. And of course, released only as a promotional CD at the time of the film's release.
The link is to be found in the comments